Decitabine

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GRAND WUYAO (JIANGSU) PHARMACEUTICAL CO., LTD

Business Type:Manufacturer

Country/Region:China

Ddu Verified

HOT Rank

6/10

Product Information

  • Active Ingredients:Decitabine
  • Chemical Formula:C₈H₁₂N₄O₄
  • Molecular Weight:228.21
  • Pharmacopeia:EP
  • Package Type:1kg
  • Shelf Life:2 years
  • Storage:Protected from light
  • Place of Origin:China

Description

1. Basic Identification
  • English Name: Decitabine API
  • CAS Number: 2353-33-5
  • Molecular Formula: C₈H₁₂N₄O₄
  • Molecular Weight: 228.21 g/mol


2. Physical Properties
  • Appearance: White to off-white crystalline powder
  • Solubility: Slightly soluble in water, soluble in DMSO, sparingly soluble in ethanol
  • Storage Conditions: Store at 2-8°C (refrigerated), protected from light and moisture, in airtight containers


3. Pharmaceutical Uses
  • Indications: Used for treating myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and other hematological malignancies.
  • Mechanism of Action: Inhibits DNA methyltransferase, reactivates tumor suppressor genes, and induces differentiation/apoptosis in cancer cells.
  • Route of Administration: Typically formulated as injectable solutions (IV or subcutaneous injection).


4. Quality Standards
  • Pharmacopoeia Compliance: USP (US), EP (EU), ChP (China), etc.
  • Key Quality Indicators:
    • Purity ≥99.0% (HPLC)
    • Impurity limits, residual solvents, and heavy metals compliant with ICH guidelines


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