Pemetrexed Disodium

  • Favorite
GRAND WUYAO (JIANGSU) PHARMACEUTICAL CO., LTD

Business Type:Manufacturer

Country/Region:China

Ddu Verified

HOT Rank

6/10

Product Information

  • Active Ingredients:Pemetrexed Disodium
  • Chemical Formula:C₂₀H₂₁N₅Na₂O₆
  • Molecular Weight:529.40
  • Pharmacopeia:USP
  • Package Type:1kg
  • Shelf Life:2 years
  • Storage:Protected from light
  • Place of Origin:China

Description

Basic Information
  • English Name: Pemetrexed Disodium
  • CAS Number: 150399-23-8
  • Molecular Formula: C₂₀H₂₁N₅Na₂O₆
  • Molecular Weight: 529.40 g/mol (sodium salt form)
  • ATC Code: L01BC20 (Antineoplastic agents, antimetabolites)


Structural Characteristics
  • Chemical Structure: A multitargeted antifolate agent, containing a pyrazole-pyrimidine core structure with glutamic acid moiety.
  • Mechanism of Action: Inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase, blocking folate-dependent nucleotide synthesis and tumor cell proliferation.


Pharmacological Properties
  • Therapeutic Use:
    • Mainly indicated for non-small cell lung cancer (NSCLC, in combination with cisplatin) and mesothelioma (pleural or peritoneal).
    • Also used in other tumors (e.g., breast cancer, ovarian cancer) in some regimens.
  • Route of Administration: Intravenous infusion after reconstitution.
  • Pharmacokinetics: Primarily excreted unchanged in urine, with minimal metabolism.


Standards and Specifications
  • Pharmacopoeia Compliance: Meets standards of USP, EP, ChP, and other major pharmacopoeias.
  • Key Quality Indicators:
    • Purity: ≥98.5% (HPLC).
    • Related Substances: Strict limits for impurities (e.g., pemetrexed acid, intermediates).
    • Residual Solvents, Heavy Metals, Water Content, and Microbiological Tests.


Storage and Handling
  • Storage Conditions: Store in a cool, dry place, protected from light and moisture.


You Might Also Like
Change a group
Inquiry Cart(0)