lrinotecan Hydrochloride

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GRAND WUYAO (JIANGSU) PHARMACEUTICAL CO., LTD

Business Type:Manufacturer

Country/Region:China

Ddu Verified

HOT Rank

6/10

Product Information

  • Active Ingredients:lrinotecan Hydrochloride
  • Chemical Formula:C₃₃H₃₈N₄O₆·HCl
  • Molecular Weight:624.15
  • Pharmacopeia:EP
  • Package Type:1kg
  • Shelf Life:2 years
  • Storage:Protected from light
  • Place of Origin:China

Description

Basic Information
  • English Name: Irinotecan Hydrochloride
  • CAS Number: 100286-90-6
  • Molecular Formula: C₃₃H₃₈N₄O₆·HCl
  • Molecular Weight: 624.15 g/mol (including hydrochloride)
  • ATC Code: L01XX08 (Antineoplastic agents)


Structural Characteristics
  • Chemical Structure: A semisynthetic derivative of camptothecin, containing a pyrrolidine piperidine ring and a camptothecin core structure.
  • Mechanism of Action: Inhibits DNA topoisomerase I, leading to DNA strand breaks and blocking tumor cell replication.


Pharmacological Properties
  • Therapeutic Use: Primarily used in the treatment of colorectal cancer (metastatic or advanced), and may also be applied to other solid tumors (such as gastric cancer, lung cancer) in combination therapies.
  • Route of Administration: Usually administered by intravenous infusion.
  • Pharmacokinetics: Metabolized in the liver, with both parent drug and active metabolites (e.g., SN-38) exerting antitumor effects.


Standards and Specifications
  • Pharmacopoeia Compliance: Complies with standards of major pharmacopoeias (e.g., USP, EP, ChP).
  • Quality Indicators: Including purity (≥98.5%), related substances, residual solvents, heavy metals, and microbial limits.


Storage and Handling
  • Storage Conditions: Store in a cool, dry place, protected from light and moisture.
  • Safety Precautions: Classified as a cytotoxic drug; requires proper personal protective equipment (PPE) and specialized handling in production and storage.


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